Low Carb Pizza Casserole is the perfect mix of pizza and lasagna—some even call it pizza lasagna! It features a cheesy cauliflower rice crust, a hearty layer of seasoned ground beef in a tomato sauce, and is topped with melty mozzarella and pepperoni slices.
This high-protein, diabetic-friendly, gluten-free comfort food is packed with flavor and easy to make for a satisfying meal.
This easy pizza casserole is perfect for a quick dinner or meal prep. It’s a satisfying and comforting dish that keeps carbs in check while still delivering that classic pizza taste the whole family will love.
If you are looking for more pizza recipes, why not try this delicious Zero Carb Crust Pizza recipe or this Diabetic Pizza recipe made with almond flour. For an easy super thin crust pizza you might enjoy this Low Carb Lavash Bread Pizza recipe. If you are a fan of rueben sandwiches you will love this Low Carb Reuben Pizza. For a delicious and easy casserole recipe, this Low Carb Italian Chicken Veggie Casserole is a must.
Jump To:
Why you'll love this diabetic pizza casserole recipe?
- All the Pizza Flavor – Get the classic taste of pizza without the carbs.
- Diabetic-Friendly & Gluten-Free – a high protein meal made with wholesome, blood sugar-friendly ingredients.
- Easy to Make – Simple prep for a quick, satisfying meal.
- Perfect for Meal Prep – Great for leftovers and reheats well.
- Customizable – Add your favorite toppings for a personal touch.
Ingredients used
* See the recipe card for a complete list of ingredients and measurements.
This easy low carb pizza casserole has all the delicious flavors of pizza without the crust, making it a healthy low carb dinner for anyone looking for a diabetic-friendly and gluten-free meal.
- Pepperoni: Use pork, beef or turkey pepperoni.
- Cauliflower Rice: we use frozen cauliflower rice, it has a finer cleaner texture making it easier to work with.
- Ground Beef: you can use other ground meats in this recipe, we like using beef.
- Cheese: we used shredded mozzarella and slices of provolone cheese to layer on top of the cauliflower crust.
- Tomato Sauce: use a low carb sauce like Rao's or any no sugar added marinara to keep carbs in check. Look for a sauce with simple ingredients and no added sugars for the best diabetic-friendly option.
- Italian Seasoning: we use Italian seasoning to add extra pizza flavor to this recipe and give it a rich, herby taste with hints of oregano, basil, and garlic for that classic Italian-inspired touch.
- Onion, Red Pepper, Garlic, Salt, Black Pepper and Olive Oil
Step by step instructions
How to make a low carb pizza casserole?
- Step 1: Make the cauliflower crust layer.
- Step 2: Make the ground beef layer.
STEP 1: Add the frozen (thawed) cauliflower rice to a large frying pan over medium heat. Fry until all the moisture is removed and the cauliflower rice is a little crispy. Add the salt, black pepper and Italian seasoning and mix through.
Add the tomato sauce and mix through until warm, then add the shredded mozzarella cheese. The cheese will help to keep the cauliflower rice together.
STEP 2: In a large frying pan sauté the onion, garlic, and red pepper with the olive oil, salt, and black pepper until softened. Then add the ground beef and cook until browned. Lastly, add the tomato sauce and mix through until warm.
- Step 3: Assemble the casserole with the cauliflower crust layer.
- Step 4: Add provolone slices.
STEP 3: Preheat your oven to 375°F
Grease the casserole dish with a pad of butter. I used a paper towel to smear it in every nook and cranny.
Transfer the cauliflower rice mixture to the buttered casserole dish and spread it out evenly, then flatten it with the back of a wooden spoon.
STEP 4: Layer the cauliflower rice mixture with provolone slices.
- Step 5: Add the ground beef layer.
- Step 6: Add cheese, pepperoni and bake.
STEP 5: Layer the ground beef mixture on top of the provolone slices and pat it down gently with the back of a spatula, just to press it into an even layer.
STEP 6: Top the ground beef mixture with the shredded mozzarella cheese, oregano and the pepperoni slices.
Bake at 375°F for 20-25 minutes and then broil for about 3-5 minutes until nice and bubbly. Watch it at 3 minutes and make sure the pepperoni does not burn.
* See the recipe card for a complete list of ingredients and instructions.
Tried this recipe? If so, please leave a comment and ⭐️⭐️⭐️⭐️⭐️ rating.
Recipe Card
Low Carb Pizza Casserole (Gluten Free and Diabetic Friendly)
Equipment
Ingredients
Cauliflower Rice Layer
- 4 cups frozen cauliflower rice thawed
- ¼ teaspoon salt
- ¼ teaspoon black pepper
- 1 tablespoon italian seasoning
- 1 cup raos tomato sauce or your preferred low sugar tomato sauce
- ½ cup mozzarella shredded
Ground Beef Layer
- 1 tablespoon olive oil
- ½ medium onion diced
- 2 garlic cloves minced
- ½ red pepper diced
- ¼ teaspoon salt
- ¼ teaspoon black pepper
- 2 lbs ground beef
- 1 cup raos tomato sauce or your preferred low sugar tomato sauce. Add more if you like it saucy.
Assembly Ingredients
- 6 slices provolone cheese
- 1 cup mozzarella shredded
- 1 teaspoon oregano
- 20 slices pepperoni pork, beef or turkey pepperoni
- butter for greasing casserole dish
Instructions
- Cook thawed cauliflower rice in a pan over medium heat until dry and slightly crispy. Stir in salt, black pepper, and Italian seasoning. Add tomato sauce and warm through, then mix in shredded mozzarella until melted.4 cups frozen cauliflower rice, ¼ teaspoon salt, ¼ teaspoon black pepper, 1 tablespoon italian seasoning, 1 cup raos tomato sauce, ½ cup mozzarella
- In another pan, heat olive oil and sauté onion, garlic, and red pepper with salt and black pepper until soft. Add ground beef and cook until browned. Stir in tomato sauce and heat through.1 tablespoon olive oil, ½ medium onion, 2 garlic cloves, ½ red pepper, ¼ teaspoon salt, ¼ teaspoon black pepper, 2 lbs ground beef, 1 cup raos tomato sauce
- Preheat oven to 375°F and grease a casserole dish with butter. Spread cauliflower rice mixture evenly in the dish and press it down.
- Layer provolone slices over the cauliflower rice.6 slices provolone cheese
- Spread the ground beef mixture on top and press it down gently.
- Top with shredded mozzarella, oregano, and pepperoni slices.1 cup mozzarella, 1 teaspoon oregano, 20 slices pepperoni
- Bake for 20-25 minutes, then broil for 3-5 minutes until bubbly. Watch closely to prevent burning.
Important Information
For more information, tips and variations please review the recipe video and content above and below the recipe card.
Updates and Revisions
If the video and recipe card differ, follow the recipe card for the latest ingredients and instructions.
Nutritional Information
Nutrition info is estimated and varies by ingredients, measurements, and portions.
Nutrition
Recipe Tips
- Press down the layers to ensure they hold together and bake evenly.
- Watch while broiling to prevent the pepperoni from burning and get a perfect crispy and bubbly finish.
Variations
- Veggie Lover’s: Add zucchini, mushrooms, and spinach to the ground beef mixture for a veggie-packed casserole.
- Spicy Kick: Top with sliced hot peppers and a sprinkle of red pepper flakes for a bit of heat.
- Italian Sausage: Swap ground beef for Italian sausage for a flavorful twist and extra savory taste.
What to serve with this pizza casserole?
- Easy Burrata Caprese Salad: featuring creamy fresh burrata, succulent cherry tomatoes, and aromatic basil pesto.
- Low Carb Green Bean Salad with Feta: fresh green beans with a tangy dressing, feta cheese and crunchy nuts.
- Roasted Brussels Sprout and Asparagus: roasted in the oven to bring out the caramelized nutty flavors of these delicious vegetables.
Storage
- Storage: Store leftovers in an airtight container in the fridge for up to 3-4 days.
- Reheat: Reheat in the microwave or oven until warmed through. If using the oven, cover with foil to prevent drying out.
- Freezing: This casserole can be frozen. Store in an airtight container for up to 3 months. Thaw overnight in the fridge before reheating.
Meal Prep Recipes!
Discover simple and delicious meal prep ideas tailored for a diabetic-friendly, low-carb lifestyle.
Frequently Asked Questions
Yes! You can swap mozzarella for other cheeses like cheddar, provolone, or parmesan depending on your preference.
Absolutely! Prepare the casserole up to the point of baking, cover it, and store it in the fridge for up to 24 hours before baking.
Yes, this casserole is great for meal prep! It stores well in the fridge for a few days or can be frozen for later.
More low carb casserole recipes
Food safety
- Cook to a minimum temperature of 165 °F (74 °C)
- Do not use the same utensils on cooked food, that previously touched raw meat
- Wash hands after touching raw meat
- Don't leave food sitting out at room temperature for extended periods
- Never leave cooked food unattended
- Use oils with high smoking point to avoid harmful compounds
- Always have good ventilation when using a gas stove
See more food guidelines
Mario says
This was so flavourful and better than any pizza.